Luteinizing Hormone/Chorionic Gonadotropin Bioactivity in the Common Marmoset (Callithrixjacchus) is Due to a Chorionic Gonadotropin Molecule with a Structure Intermediate between Human Chorionic Gonadotropin and Human Luteinizing Hormone
نویسندگان
چکیده
منابع مشابه
Luteinizing hormone and human chorionic gonadotropin: distinguishing unique physiologic roles
Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are integral components of the hypothalamic-pituitary-gonadal axis, which controls sexual maturation and functionality. In the absence of signaling through their shared receptor, fetal sexual differentiation and post-natal development cannot proceed normally. Although they share a high degree of homology, the physiologic roles of t...
متن کاملLuteinizing hormone and human chorionic gonadotropin: Origins of difference
Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are widely recognized for their roles in ovulation and the support of early pregnancy. Aside from the timing of expression, however, the differences between LH and hCG have largely been overlooked in the clinical realm because of their similar molecular structures and shared receptor. With technologic advancements, including the de...
متن کاملTargeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene.
LH/hCG receptors were disrupted by gene targeting in embryonic stem cells. The disruption resulted in infertility in both sexes. The gonads contained no receptor mRNA or receptor protein. Serum LH levels were greatly elevated, and FSH levels were moderately elevated in both sexes; estradiol and progesterone levels decreased but were not totally suppressed in females; testosterone levels were dr...
متن کاملIdentification and Characterization of Contact Sites between Human Chorionic Gonadotropin and Luteinizing Hormone/choriogonadotropin Receptor
OF DISSERTATION
متن کاملIncreased Human Chorionic Gonadotropin Due to Hypogonadism
nonsignificant differences between cutoffs for serum and plasma and between assays are encouraging regarding the ease of interpretation by clinicians and laboratories. Also encouraging were improvements in the analytical sensitivity of these newergeneration assays. Interestingly, only 3 samples were identified as above the 99th percentile by all 3 assays. The mechanisms responsible for this lac...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1995
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod53.2.380